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KMID : 0360320000320030497
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Journal of Korean Cancer Research Association
2000 Volume.32 No. 3 p.497 ~ p.505
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Interrelation between the Progression of Gastric Adenocarcinoma and the Matrix Metalloproteinases
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Lim Sung-Chul
Lee Mi-Ja
Park Chan-Guk
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Abstract
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Purpose :An essential element in tumor invasion and metastasis in the degradation of extracellular matrix in matrix Metalloproteinases (MMPs). But little is known about the role of them in the gastric adenocarcinoma. The purpose of this study was to determine whether human gastric adenocarcinoma expressed MMPs and whether MMPs were concerned in tumor stage and histologic subtypes.
Materials and Methods : The authors performed the retroactive analysis in 38 cases of early gastric carcinoma (EGC) and 61 cases of advanced gastric carcinoma (AGC), including 38 cases of diffuse type and 61 cases of intestinal type, using immunohistochemical staining for MMP-2, -3 and -9.
Results :MMP-2, -3 and -9 were localized to neoplastic cells in 93% (92/99 ), 32% (32/99) and 76% (76/99), respectively. MMP-2 and -9 were found mainly in tumors of intestinal type and less frequently in those of diffuse type. There were positive correlation between the presence of MMP-2 and -9 and lymph node metastasis. There was positive correlation between MMP-2 expression and tumor stage.
Conclusion :The authors demonstrated a statistically significant expression of tumoral MMP-2, -3 and -9 in gastric adenocarcinoma and their correlation with tumor progression. This study also suggests that the presence of MMP-2 and/or -9 is a useful indicator for poor prognosis.
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KEYWORD
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Stomach neoplasm, Matrix metalloproteinase,
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